Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins
نویسندگان
چکیده
منابع مشابه
Transactivation of the human c-myc gene by c-Myb.
We analyse the contribution of six Myb-binding sites in the upstream c-myc sequences to transactivation by co-transfection assays. Surprisingly, deletion of the six Myb-binding sites did not influence the transactivation of c-myc by c-Myb protein. Instead, the strongest transactivation was observed with a c-myc reporter plasmid which contains only 450 bp of exon 1 including the c-myc promoter P...
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Nucleolar localization of box C/D small nucleolar (sno) RNAs requires the box C/D motif and, in vertebrates, involves transit through Cajal bodies (CB). We report that in yeast, overexpression of a box C/D reporter leads to a block in the localization pathway with snoRNA accumulation in a specific sub-nucleolar structure, the nucleolar body (NB). The human survival of motor neuron protein (SMN)...
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c-myc and c-myb mRNA have been found to be tightly regulated during haemopoietic differentiation [1]. While the expression of both oncogenes is induced in cells stimulated to proliferate, c-myc in the transition from Go to G 1 [2], and c-myb in the transition from G 1 to S phase [3], expression ceases in terminally differentiating haemopoietic cell lines. This takes the form of a progressive mo...
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The c-myc oncogene and its viral counterpart v-myc encode phosphoproteins which have been located within cell nuclei, excluding nucleoli. We have expressed the c-myc gene under the simian virus 40 early promoter and studied the distribution of its protein product in transient expression assays in COS, HeLa, and 293 cells. We found three distinct patterns of c-myc immunofluorescence in the trans...
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Glucocorticoid hormone treatment of certain T-cell-derived lymphomas and leukemias and of immature thymocytes results in cell death. Furthermore, glucocorticoid-mediated killing of S49 mouse lymphoma cells appears to involve the control of the cell cycle; i.e., S49 cells treated with glucocorticoids are arrested in G1 of the cell cycle when events controlling cell proliferation occur. The proto...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)84673-2